Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins

@article{Brownawell2002Exportin5AN,
  title={Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins},
  author={Amy M. Brownawell and Ian G. Macara},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={156},
  pages={53 - 64}
}
We have identified a novel human karyopherin (Kap) beta family member that is related to human Crm1 and the Saccharomyces cerevisiae protein, Msn5p/Kap142p. Like other known transport receptors, this Kap binds specifically to RanGTP, interacts with nucleoporins, and shuttles between the nuclear and cytoplasmic compartments. We report that interleukin enhancer binding factor (ILF)3, a double-stranded RNA binding protein, associates with this Kap in a RanGTP-dependent manner and that its double… CONTINUE READING
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