Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor.

  title={Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor.},
  author={Gayatri Yatherajam and Wenying Huang and S. Jane Flint},
  journal={Journal of virology},
  volume={85 4},
One important function of the human adenovirus E1B 55-kDa protein is induction of selective nuclear export of viral late mRNAs. This protein interacts with the viral E4 Orf6 and four cellular proteins to form an infected-cell-specific E3 ubiquitin ligase. The assembly of this enzyme is required for efficient viral late mRNA export, but neither the relevant substrates nor the cellular pathway that exports viral late mRNAs has been identified. We therefore examined the effects on viral late gene… CONTINUE READING
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