Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts

@article{Nordgren2015ExportdeficientMP,
  title={Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts},
  author={M. Nordgren and T. Francisco and Celien Lismont and Lore Hennebel and C. Brees and B. Wang and P. V. Van Veldhoven and Jorge E Azevedo and M. Fransen},
  journal={Autophagy},
  year={2015},
  volume={11},
  pages={1326 - 1340}
}
Peroxisomes are ubiquitous cell organelles essential for human health. To maintain a healthy cellular environment, dysfunctional and superfluous peroxisomes need to be selectively removed. Although emerging evidence suggests that peroxisomes are mainly degraded by pexophagy, little is known about the triggers and molecular mechanisms underlying this process in mammalian cells. In this study, we show that PEX5 proteins fused to a bulky C-terminal tag trigger peroxisome degradation in SV40 large… Expand
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