Export and functions of sphingosine-1-phosphate.

  title={Export and functions of sphingosine-1-phosphate.},
  author={Roger Kim and Kazuaki Takabe and Sheldon Milstien and Sarah Spiegel},
  journal={Biochimica et biophysica acta},
  volume={1791 7},
The sphingolipid metabolite, sphingosine-1-phosphate (S1P), has emerged as a critical player in a number of fundamental biological processes and is important in cancer, angiogenesis, wound healing, cardiovascular function, atherosclerosis, immunity and asthma, among others. Activation of sphingosine kinases, enzymes that catalyze the phosphorylation of sphingosine to S1P, by a variety of agonists, including growth factors, cytokines, hormones, and antigen, increases intracellular S1P. Many of… CONTINUE READING

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