Export-Mediated Assembly of Mycobacterial Glycoproteins Parallels Eukaryotic Pathways

  title={Export-Mediated Assembly of Mycobacterial Glycoproteins Parallels Eukaryotic Pathways},
  author={B. VanderVen and J. Harder and D. Crick and J. Belisle},
  pages={941 - 943}
  • B. VanderVen, J. Harder, +1 author J. Belisle
  • Published 2005
  • Medicine, Biology
  • Science
  • Protein O-mannosylation is an essential and evolutionarily conserved post-translational modification among eukaryotes. This form of protein modification is also described in Mycobacterium tuberculosis; however, the mechanism of mannoprotein assembly remains unclear. Evaluation of differentially translocated chimeric proteins and mass spectrometry to monitor glycosylation demonstrated that specific translocation processes were required for protein O-mannosylation in M. tuberculosis. Additionally… CONTINUE READING
    258 Citations
    Protein O-mannosylation: conserved from bacteria to humans.
    • 178
    • Highly Influenced
    • PDF
    New insights into protein O-mannosylation in actinomycetes.
    • 25
    Sweet New Roles for Protein Glycosylation in Prokaryotes.
    • 28
    • PDF
    Protein-O-mannosyltransferases in virulence and development
    • 55
    Structure of the eukaryotic protein O-mannosyltransferase Pmt1–Pmt2 complex
    • 5
    Bacterial protein-O-mannosylating enzyme is crucial for virulence of Mycobacterium tuberculosis
    • 55
    • Highly Influenced
    • PDF
    Emerging themes in SecA2-mediated protein export
    • 70


    Protein O-mannosylation.
    • 276
    O-mannosyl glycans: from yeast to novel associations with human disease.
    • 145
    Sweet new world: glycoproteins in bacterial pathogens.
    • 180
    Targeting and assembly of periplasmic and outer-membrane proteins in Escherichia coli.
    • 215