Export-Mediated Assembly of Mycobacterial Glycoproteins Parallels Eukaryotic Pathways

@article{VanderVen2005ExportMediatedAO,
  title={Export-Mediated Assembly of Mycobacterial Glycoproteins Parallels Eukaryotic Pathways},
  author={B. VanderVen and J. Harder and D. Crick and J. Belisle},
  journal={Science},
  year={2005},
  volume={309},
  pages={941 - 943}
}
Protein O-mannosylation is an essential and evolutionarily conserved post-translational modification among eukaryotes. This form of protein modification is also described in Mycobacterium tuberculosis; however, the mechanism of mannoprotein assembly remains unclear. Evaluation of differentially translocated chimeric proteins and mass spectrometry to monitor glycosylation demonstrated that specific translocation processes were required for protein O-mannosylation in M. tuberculosis. Additionally… Expand
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