Exponential growth for self-reproduction in a catalytic reaction network: relevance of a minority molecular species and crowdedness

  title={Exponential growth for self-reproduction in a catalytic reaction network: relevance of a minority molecular species and crowdedness},
  author={Atsushi Kamimura and Kunihiko Kaneko},
  journal={New Journal of Physics},
Explanation of exponential growth in self-reproduction is an important step toward elucidation of the origins of life because optimization of the growth potential across rounds of selection is necessary for Darwinian evolution. To produce another copy with approximately the same composition, the exponential growth rates for all components have to be equal. How such balanced growth is achieved, however, is not a trivial question, because this kind of growth requires orchestrated replication of… 

Molecular Diversity and Network Complexity in Growing Protocells

New light is shed on the origin of molecular diversity and complex reaction network at the primitive stage of a cell and how these develop through the evolutionary course.

Horizontal transfer between loose compartments stabilizes replication of fragmented ribozymes

The results underline compartmentalization and horizontal transfer in the origin of the first self-replicating replicases through negative frequency-dependent selection operating in the population dynamics of compartments and the balanced production of all fragments.



Compartmentalization and Cell Division through Molecular Discreteness and Crowding in a Catalytic Reaction Network

The reproduction of a localized cluster is demonstrated, that is, a protocell with a growth-division process emerges when the replication and degradation speeds of one species are respectively slower than those of the other species, because of overcrowding of molecules as a natural outcome of the replication.

Formation of Dominant Mode by Evolution in Biological Systems

Consequences of evolutionary robustness is investigated, which is shown to cause a stronger dimensional reduction in possible phenotypic changes in response to a variety of environmental conditions, and a theory in which high-dimensional phenotypesic changes after evolution are constrained to the points near a one-dimensional major axis that correlates with the growth rate is proposed.

Reproduction of a protocell by replication of a minority molecule in a catalytic reaction network.

It is observed that the protocell divides after a minority molecule is replicated at a slow synthesis rate, and thus, a synchrony between the reproduction of a cell and molecule replication is achieved and the robustness of such protocells against the invasion of parasitic molecules is demonstrated.

Transition to diversification by competition for multiple resources in catalytic reaction networks

The results indicate that a simple physical principle of competition for a variety of limiting resources can be a strong driving force to diversify intracellular dynamics of a catalytic reaction network and to develop diverse protocell types in a primitive stage of life.

On a kinetic origin of heredity: minority control in a replicating system with mutually catalytic molecules.

The minority molecule species act as the carrier of heredity, due to the relatively discrete nature of its population, in comparison with the majority species which behaves statistically in accordance with the law of large numbers.

On Recursive Production and Evolvability of Cells: Catalytic Reaction Network Approach

The present survey paper first formulate basic questions on the recursiveness and evolvability of a cell, and then state the standpoint of the research to answer the questions, that is termed as 'constructive biology'.

Transition to diversification by competition for resources in catalytic reaction networks

It is found that a transition to diversity occurs both in chemical compositions and in protocell types, as the resource supply is decreased, when the maximum inflow and consumption of resources are balanced.

Adaptation of autocatalytic fluctuations to diffusive noise.

The model is explored by employing field theoretical techniques, numerical simulations, and strong coupling analysis, and the applicability of this model as a prototype for a host of phenomena that exhibit self-organization is discussed.

Compositional genomes: prebiotic information transfer in mutually catalytic noncovalent assemblies.

This analysis addresses the question of how mutually catalytic metabolic networks, devoid of sequence-based biopolymers, could exhibit transfer of chemical information and might undergo selection and evolution.