Explosive autotomy induced by simultaneous dorsal column lesion and limb denervation: a possible model for acute deafferentation pain.

@article{Saad1993ExplosiveAI,
  title={Explosive autotomy induced by simultaneous dorsal column lesion and limb denervation: a possible model for acute deafferentation pain.},
  author={Nayef E. Saad{\'e} and Mohamad Z.M. Ibrahim and Samir F Atweh and Suhayl J Jabbur},
  journal={Experimental neurology},
  year={1993},
  volume={119 2},
  pages={272-9}
}
We report on a new "explosive" form of self-mutilation behavior (autotomy) characterized by rapid onset (1-2 days), short duration (1-2 days), and unpredictable progression. The possible neural mechanism(s) underlying this novel behavior were examined in rats by combining at varying time intervals one leg denervation with a lesion to the dorsal columns (DC lesion) or to a dorsolateral funiculus (DLF lesion). DC lesion, followed immediately by leg denervation, resulted in explosive autotomy in… CONTINUE READING