Corpus ID: 83773253

Exploring thioredoxin reductase as an anticancer drug target

@inproceedings{PrastNielsen2009ExploringTR,
  title={Exploring thioredoxin reductase as an anticancer drug target},
  author={S. Prast-Nielsen},
  year={2009}
}
Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. The mammalian thioredoxin (Trx) system exerts an impressive spectrum of functions either directly through reactions catalyzed by TrxR or by its prime substrate Trx. It is involved in redox regulation, antioxidant defense, cell growth, replication and regulation of transcription factors. TrxR was found to be overexpressed in a variety of… Expand

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