Exploring the unique N-glycome of the opportunistic human pathogen Acanthamoeba.

  title={Exploring the unique N-glycome of the opportunistic human pathogen Acanthamoeba.},
  author={Birgit Schiller and Georgia Makrypidi and Ebrahim Razzazi-Fazeli and Katharina Paschinger and Julia Walochnik and Iain B H Wilson},
  journal={The Journal of biological chemistry},
  volume={287 52},
Glycans play key roles in host-pathogen interactions; thus, knowing the N-glycomic repertoire of a pathogen can be helpful in deciphering its methods of establishing and sustaining a disease. Therefore, we sought to elucidate the glycomic potential of the facultative amoebal parasite Acanthamoeba. This is the first study of its asparagine-linked glycans, for which we applied biochemical tools and various approaches of mass spectrometry. An initial glycomic screen of eight strains from five… CONTINUE READING
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