Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy.

@article{Micke2005ExploringTT,
  title={Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy.},
  author={Patrick Micke and Arne Ostman},
  journal={Expert opinion on therapeutic targets},
  year={2005},
  volume={9 6},
  pages={1217-33}
}
Stroma cells contribute to the microenvironment that is essential for cancer growth, invasion and metastatic progression. Fibroblasts, often termed myofibroblasts or cancer-associated fibroblasts (CAFs), represent the most abundant cell type in the tumour stroma. The demonstrated tumour-promoting capacities of CAFs has increased the interest to exploit them as drug targets for anticancer therapy. Although single factors, such as platelet-derived growth factor, transforming growth factor-beta1… CONTINUE READING
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