Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools.

@article{Sharom2001ExploringTS,
  title={Exploring the structure and function of the P-glycoprotein multidrug transporter using fluorescence spectroscopic tools.},
  author={Frances Jane Sharom and Ronghua Liu and Qin Qu and Y Romsicki},
  journal={Seminars in cell & developmental biology},
  year={2001},
  volume={12 3},
  pages={257-65}
}
P-glycoprotein is an ABC protein that functions as an efflux pump for multiple drugs, natural products and peptides. It is proposed to operate as a hydrophobic vacuum cleaner, expelling non-polar compounds from the membrane bilayer to the exterior, driven by the energy of ATP hydrolysis. The nucleotide-binding domains of P-glycoprotein appear to operate by an alternating sites mechanism to power drug transport. In recent years, purification and functional reconstitution of the protein has… CONTINUE READING

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