Exploring the specificity of the PI3K family inhibitor LY294002.

@article{Gharbi2007ExploringTS,
  title={Exploring the specificity of the PI3K family inhibitor LY294002.},
  author={Severine I. Gharbi and Marketa J. Zvelebil and Stephen J. Shuttleworth and Tim Hancox and Nahid Saghir and John F Timms and Michael D. Waterfield},
  journal={The Biochemical journal},
  year={2007},
  volume={404 1},
  pages={
          15-21
        }
}
The PI3Ks (phosphatidylinositol 3-kinases) regulate cellular signalling networks that are involved in processes linked to the survival, growth, proliferation, metabolism and specialized differentiated functions of cells. The subversion of this network is common in cancer and has also been linked to disorders of inflammation. The elucidation of the physiological function of PI3K has come from pharmacological studies, which use the enzyme inhibitors Wortmannin and LY294002, and from PI3K genetic… CONTINUE READING

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