Exploring the specificity of bacterial elongation factor Tu for different tRNAs.

@article{Sanderson2007ExploringTS,
  title={Exploring the specificity of bacterial elongation factor Tu for different tRNAs.},
  author={Lee Edward Sanderson and O. C. Uhlenbeck},
  journal={Biochemistry},
  year={2007},
  volume={46 21},
  pages={6194-200}
}
In order to identify amino acids in Thermus thermophilus elongation factor Tu which contribute to its specificity for different tRNAs, the binding affinities of 20 point mutations were compared to that of wild type protein using four tRNAs of differing affinities. The observed specificity for tRNA is the result of the varying contributions of five amino… CONTINUE READING