Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats.

@article{Trivedi2003ExploringTS,
  title={Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats.},
  author={Prashant Trivedi and Michael Jiang and Constantin Tamvakopoulos and Xiaolan Shen and Hong Xiang Yu and Steven J. Mock and Judy E. Fenyk-Melody and Lex H. T. van der Ploeg and Xiao-ming Guan},
  journal={Brain research},
  year={2003},
  volume={977 2},
  pages={221-30}
}
Melanotan-II (MT-II), a cyclic heptapeptide, is a potent, non-selective melanocortinergic agonist. When administered centrally or systemically, MT-II elicited a profound inhibitory effect on food intake in rodents, presumably via activation of melanocortin-4-receptor (MC4R). In this study, we sought to investigate whether penetration of MT-II and iodo-MT-II into brain parenchyma is required for the anorectic effect following intravenous (IV) administration. Firstly, both MT-II and iodo-MT-II… CONTINUE READING
16 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…