Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels.

  title={Exploring the sequence space for (tri-)peptide self-assembly to design and discover new hydrogels.},
  author={Pim W. J. M. Frederix and Gary G Scott and Yousef M Abul-Haija and Daniela Kalafatovic and Charalampos G Pappas and Nadeem Javid and Neil T. Hunt and Rein V Ulijn and Tell Tuttle},
  journal={Nature chemistry},
  volume={7 1},
Peptides that self-assemble into nanostructures are of tremendous interest for biological, medical, photonic and nanotechnological applications. The enormous sequence space that is available from 20 amino acids probably harbours many interesting candidates, but it is currently not possible to predict supramolecular behaviour from sequence alone. Here, we demonstrate computational tools to screen for the aqueous self-assembly propensity in all of the 8,000 possible tripeptides and evaluate these… CONTINUE READING
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self - assemble into nanospheres and nanorods that are different from the nanovesicles and nanotubes formed by diphenylalanine peptides

  • D. Thirumalai, D. Klimov, R. Dima
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