Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans

@inproceedings{Houweling2017ExploringTR,
  title={Exploring the relationship between α-actinin-3 deficiency and obesity in mice and humans},
  author={Peter J Houweling and Yemima D Berman and Nigel Turner and Kate G. R. Quinlan and Jane T C Seto and Nan Yang and Monkol Lek and Daniel G. MacArthur and Greg J Cooney and Kathryn N North},
  booktitle={International Journal of Obesity},
  year={2017}
}
Obesity is a worldwide health crisis, and the identification of genetic modifiers of weight gain is crucial in understanding this complex disorder. A common null polymorphism in the fast fiber-specific gene ACTN3 (R577X) is known to influence skeletal muscle function and metabolism. α-Actinin-3 deficiency occurs in an estimated 1.5 billion people worldwide, and results in reduced muscle strength and a shift towards a more efficient oxidative metabolism. The X-allele has undergone strong… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 10 times. VIEW TWEETS

Citations

Publications citing this paper.

ACTN3, Morbidity, and Healthy Aging

Front. Genet. • 2018
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Advances in exercise, fitness, and performance genomics

L Perusse, T Rankinen, +3 authors MA Sarzynski
Med Sci Sports Exerc • 2012

Similar Papers

Loading similar papers…