Exploring the potential of minoxidil tretinoin liposomal based hydrogel for topical delivery in the treatment of androgenic alopecia

  title={Exploring the potential of minoxidil tretinoin liposomal based hydrogel for topical delivery in the treatment of androgenic alopecia},
  author={Pratiksha Kochar and Kritika Nayak and Shreya Thakkar and Suryanarayana Polaka and Dignesh Khunt and Manju Misra},
  journal={Cutaneous and Ocular Toxicology},
  pages={43 - 53}
Abstract Purpose: Androgenic alopecia (AGA) is a condition of progressive hair loss and involves follicular miniaturization triggered mainly due to varying levels of androgen besides environmental and genetic factors, which may also play some role. Minoxidil (MXD) has been considered as most effective therapeutic moiety to treat this disorder. Another drug Tretinoin (TRET) is known for its comedolytic activity and is reported to enhance percutaneous absorption of MXD. Presently both these drugs… 

Recent Advances in Topical Nanotechnological Strategies for Treatment of Alopecia

This review provides an in-depth study of developed nanocarriers like liposomes, nano-emulsions, ethosomes, solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs) along with their composition, method of preparation, results obtained after formulation, suitable use andAlong with their potential use in treatment of different forms of alopecia.

Cyclosporin A-loaded poly(d,l-lactide) nanoparticles: a promising tool for treating alopecia.

This work fosters further in vivo investigation of CsA-loaded PLA nanoparticles as a promising new strategy to treat alopecia, a very traumatic, possibly autoimmune, disease.

Controlled drug delivery for alopecia: A review.

  • S. ShefrinK. Kaladhar
  • Biology, Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 2020


The synthesized formulation is expected to combine the benefit of small size and structural similarity of the lipid nanocarriers and skin to achieve effective targeting of the diseased skin for psoriasis management.

Minoxidil: a comprehensive review

After 6 months of administration, minoxidil 5 mg/day was significantly more effective than topical 5% and 2% in male AGA, and low-dose 0.5–5  mg/day may also be safe and effective for female pattern hair loss and chronic telogen effluvium.

Overcoming barriers by local drug delivery with liposomes.

Applications of Nanostructured Lipid Carriers: Recent Advancements and Patent Review

This review briefly describes nanostructured lipid carriers in terms of their production techniques, characterization, recent advancements in pharmaceutical applications, and functional food delivery.



Formulation of tretinoin-loaded topical proniosomes for treatment of acne: in-vitro characterization, skin irritation test and comparative clinical study

Developing TRT-loaded proniosomes to improve the drug efficacy and to increase user acceptability and compliance by reducing its side effects showed higher efficacy and very low irritation potential when compared to marketed product in human volunteers.

Preparation and Physicochemical Characterization of Topical Niosomal Formulation of Minoxidil and Tretinoin

Skin is one of the most important tissue in the body which protects from other tissues and organs against fluid loss and foreign agents, and catagen-inducing factors stimulate apoptosis in the hair matrix cells.

In vitro and in vivo topical delivery studies of tretinoin-loaded ultradeformable vesicles.

  • A. AscensoA. Salgado S. Simões
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2014

Oleic Acid Nanovesicles of Minoxidil for Enhanced Follicular Delivery

The current findings demonstrate the potential of oleic acid vesicles for effective targeted skin and follicular delivery of MXD.

Formulation and In-vitro Evaluation of Tretinoin Microemulsion as a Potential Carrier for Dermal Drug Delivery

The optimized tretinoin microemulsion showed enhanced in-vitro release profile compared to the commercial gels and creams and showed pseudoplastic-thixotropic behavior.

Self-assembled polymeric nanocarriers for the targeted delivery of retinoic acid to the hair follicle.

The results indicate that the polymeric micelle formulation enabled an increased and targeted delivery of RA to the PSU, potentially translating to a safer and more efficient clinical management of acne.