Exploring the molecular etiology of dominant-negative mutations.

  title={Exploring the molecular etiology of dominant-negative mutations.},
  author={Reiner A. Veitia},
  journal={The Plant cell},
  volume={19 12},
Herskowitz (1987) provided the classical definition of dominantnegative (DN) mutations as those leading to mutant polypeptides that disrupt the activity of the wild-type gene when overexpressed. Although Herskowitz’ definition referred basically to intralocus interactions, it is now recognized that interlocus (e.g., trans-acting) interactions can also lead to dominance (Omholt et al., 2000) and to DN effects (DNEs; Veitia 2002). DNEs are thought to have an impact on plant genome evolution… CONTINUE READING
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