Exploring the link between ceramide and ionizing radiation

  title={Exploring the link between ceramide and ionizing radiation},
  author={Massimo Aureli and Valentina Murdica and Nicoletta Loberto and Maura Samarani and Alessandro Prinetti and Rosaria Bassi and Sandro Sonnino},
  journal={Glycoconjugate Journal},
The aim of radiotherapy is to eradicate cancer cells with ionizing radiation; tumor cell death following irradiation can be induced by several signaling pathways, most of which are triggered as a consequence of DNA damage, the primary and major relevant cell response to radiation. Several lines of evidence demonstrated that ceramide, a crucial sensor and/or effector of different signalling pathways promoting cell cycle arrest, death and differentiation, is directly involved in the molecular… CONTINUE READING


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