Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry.

@article{Rocha2012ExploringTH,
  title={Exploring the human urine metabolomic potentialities by comprehensive two-dimensional gas chromatography coupled to time of flight mass spectrometry.},
  author={S{\'i}lvia M Rocha and Michael Caldeira and Joana Carrola and Magda da Silva Santos and N{\'a}dia V.G. Cruz and Iola F Duarte},
  journal={Journal of chromatography. A},
  year={2012},
  volume={1252},
  pages={
          155-63
        }
}
Metabolomics represents an emerging issue that can aid in the diagnosis and/or prognosis of different diseases. Metabolomic study of urine is particularly interesting as it can be on the base of the developing of new faster and non-invasive methodologies. In response to this actual trend, comprehensive two-dimensional gas chromatography-time of flight mass spectrometry (GC×GC-ToFMS) combined with headspace solid phase microextraction (HS-SPME) is applied, for the first time to our knowledge, to… CONTINUE READING
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