Exploring the human genome with functional maps.

@article{Huttenhower2009ExploringTH,
  title={Exploring the human genome with functional maps.},
  author={Curtis Huttenhower and Erin M. Haley and Matthew A. Hibbs and Vanessa Dumeaux and Daniel R. Barrett and Hilary A. Coller and Olga G. Troyanskaya},
  journal={Genome research},
  year={2009},
  volume={19 6},
  pages={1093-106}
}
Human genomic data of many types are readily available, but the complexity and scale of human molecular biology make it difficult to integrate this body of data, understand it from a systems level, and apply it to the study of specific pathways or genetic disorders. An investigator could best explore a particular protein, pathway, or disease if given a functional map summarizing the data and interactions most relevant to his or her area of interest. Using a regularized Bayesian integration… CONTINUE READING