Exploring the folding landscape of a structured RNA.

@article{Russell2002ExploringTF,
  title={Exploring the folding landscape of a structured RNA.},
  author={Rick Russell and Xiaowei Zhuang and Hazen P. Babcock and Ian S. Millett and Sebastian Doniach and Steven Chu and Daniel Herschlag},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 1},
  pages={155-60}
}
Structured RNAs achieve their active states by traversing complex, multidimensional energetic landscapes. Here we probe the folding landscape of the Tetrahymena ribozyme by using a powerful approach: the folding of single ribozyme molecules is followed beginning from distinct regions of the folding landscape. The experiments, combined with small-angle x-ray scattering results, show that the landscape contains discrete folding pathways. These pathways are separated by large free-energy barriers… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 80 extracted citations

RNA 3D Structure Analysis and Prediction

Nucleic Acids and Molecular Biology • 2012
View 5 Excerpts
Highly Influenced

Kinetic and thermodynamic framework for P4-P6 RNA reveals tertiary motif modularity and modulation of the folding preferred pathway.

Proceedings of the National Academy of Sciences of the United States of America • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-8 of 8 references

New goals for the US human genome project : 1998 - 2003 . " ( 1998 )

S. R. Eddy
Science • 2001

Catalytic RNA: structure and mechanism.

Biochemical Society transactions • 1993

Small-angle X-ray scattering.

Methods in enzymology • 1979
View 1 Excerpt

A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novelgenes . " ( 2001 )

J. B. Hogenesch
Nature Genet .

Similar Papers

Loading similar papers…