Exploring the folding landscape of a structured RNA.

  title={Exploring the folding landscape of a structured RNA.},
  author={Rick Russell and Xiaowei Zhuang and Hazen P. Babcock and Ian S. Millett and Sebastian Doniach and Steven Chu and Daniel Herschlag},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 1},
Structured RNAs achieve their active states by traversing complex, multidimensional energetic landscapes. Here we probe the folding landscape of the Tetrahymena ribozyme by using a powerful approach: the folding of single ribozyme molecules is followed beginning from distinct regions of the folding landscape. The experiments, combined with small-angle x-ray scattering results, show that the landscape contains discrete folding pathways. These pathways are separated by large free-energy barriers… CONTINUE READING

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