Exploring the effect of sex on empirical fitness landscapes.

@article{Visser2009ExploringTE,
  title={Exploring the effect of sex on empirical fitness landscapes.},
  author={J. Arjan G. M. de Visser and Su-Chan Park and Joachim Krug},
  journal={The American naturalist},
  year={2009},
  volume={174 Suppl 1},
  pages={S15-30}
}
The nature of epistasis has important consequences for the evolutionary significance of sex and recombination. Recent efforts to find negative epistasis as a source of negative linkage disequilibrium and associated long-term advantage to sex have yielded little support. Sign epistasis, where the sign of the fitness effects of alleles varies across genetic backgrounds, is responsible for the ruggedness of the fitness landscape, with several unexplored implications for the evolution of sex. Here… CONTINUE READING

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