Exploring the demographic history of DNA sequences using the generalized skyline plot.

@article{Strimmer2001ExploringTD,
  title={Exploring the demographic history of DNA sequences using the generalized skyline plot.},
  author={Korbinian Strimmer and Oliver G. Pybus},
  journal={Molecular biology and evolution},
  year={2001},
  volume={18 12},
  pages={2298-305}
}
We present an intuitive visual framework, the generalized skyline plot, to explore the demographic history of sampled DNA sequences. This approach is based on a genealogy inferred from the sequences and provides a nonparametric estimate of effective population size through time. In contrast to previous related procedures, the generalized skyline plot is more applicable to cases where the underlying tree is not fully resolved and the data is not highly variable. This is achieved by the grouping… CONTINUE READING
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