Exploring the contribution of distal P4 promoter elements to the oncoselectivity of Minute Virus of Mice.

@article{Paglino2007ExploringTC,
  title={Exploring the contribution of distal P4 promoter elements to the oncoselectivity of Minute Virus of Mice.},
  author={Justin C Paglino and Erik D Burnett and Peter J Tattersall},
  journal={Virology},
  year={2007},
  volume={361 1},
  pages={174-84}
}
Minute Virus of Mice (MVM) shares inherent oncotropic properties with other members of the genus Parvovirus. Two elements responsible, at least in part, for this oncoselectivity have been mapped to an Ets1 binding site adjacent to the P4 TATA box of the initiating promoter, P4, and to a more distal cyclic AMP responsive element (CRE), located within the telomeric hairpin stem. Here the CRE overlaps one half-site for the binding of parvoviral initiation factor (PIF), which is essential for viral… CONTINUE READING