Exploring the chemistry of epoxy amides for the synthesis of the 2''-epi-diazepanone core of liposidomycins and caprazamycins.

  title={Exploring the chemistry of epoxy amides for the synthesis of the 2''-epi-diazepanone core of liposidomycins and caprazamycins.},
  author={Francisco Sarabia and Carlos Vivar-Garc{\'i}a and Cristina Garc{\'i}a-Ruiz and Laura Mart{\'i}n-Ortiz and Antonio Romero-Carrasco},
  journal={The Journal of organic chemistry},
  volume={77 3},
New synthetic strategies have been explored for the synthesis of the structural core of liposidomycins and caprazamycins, an intriguing class of complex nucleoside-type antibiotics. This structural core is comprised of a cyclic diazepanone system linked to an uridyl fragment. The various synthetic approaches have in common that they originate from an epoxy amide derived from uridine, obtained via reaction of uridyl aldehyde 19 with an amide-stabilized sulfur ylide. Two different strategies were… 

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