Exploring the chemical space of quorum sensing peptides

@article{Wynendaele2015ExploringTC,
  title={Exploring the chemical space of quorum sensing peptides},
  author={E. Wynendaele and Bert Gevaert and Sofie Stalmans and F. Verbeke and B. De Spiegeleer},
  journal={Peptide Science},
  year={2015},
  volume={104}
}
Quorum sensing peptides are signalling molecules that are produced by mainly gram‐positive bacteria. These peptides can exert different effects, ranging from intra‐ and interspecies bacterial virulence to bacterial–host interactions. To better comprehend these functional differences, we explored their chemical space, bacterial species distribution and receptor‐binding properties using multivariate data analyses, with information obtained from the Quorumpeps database. The quorum sensing peptides… Expand
Chromatography of Quorum Sensing Peptides: An Important Functional Class of the Bacterial Peptidome
Quorum sensing is the process by which bacteria communicate with each other to regulate the expression of certain genes in a cell density-dependent manner. One group of signalling molecules used inExpand
Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier
TLDR
Three chemically diverse quorum sensing peptides were investigated for their brain influx and efflux properties in an in vivo mouse model to determine blood-brain transfer properties and support the potential role of some quorum sensed peptides in different neurological disorders. Expand
Exploration of quorum sensing peptides: the missing link between microbiome and cancer outcome?
TLDR
The quality aspects of radiolabelled peptides as used not only in the biomedical research but also as diagnostics or therapeutics in the current shift towards personalized medicine are reviewed. Expand
The bacterial quorum sensing molecule, 2-heptyl-3-hydroxy-4-quinolone (PQS), inhibits signal transduction mechanisms in brain tissue and is behaviourally active in mice.
TLDR
These findings offer the first demonstration that a quorum sensing molecule specifically produced by Pseudomonas aeruginosa is centrally active and influences cell signaling and behavior. Expand
Quality evaluation of synthetic quorum sensing peptides used in R&D
TLDR
In-house quality control (QC) revealed a large discrepancy between the purity levels as stated on the supplier's certificate of analysis and the results, and found that the majority of the related impurities were lacking amino acid(s) in the desired peptide sequence. Expand
Cyclic Peptides in Neurological Disorders: The Case of Cyclo(His-Pro)
Abstract Communication between and within communities of cells or independent organisms is a crucial prerequisite for species survival. In response to variations in the extracellularExpand
Influence of Blood Collection Methods and Long-Term Plasma Storage on Quorum-Sensing Peptide Stability
TLDR
The results of this study indicate that a cost-effective tube, designed for traditional proteomics and stored at 4 °C, is the preferred collection condition when quorum-sensing peptides need to be detected/quantified in human plasma. Expand
Quorum sensing molecules as a novel microbial factor impacting muscle cells.
TLDR
These proof-of-concept findings provide the first evidence that QSM produced by microbiota play a role in the gut-muscle axis, opening new perspectives for diagnostic and therapeutic targets in muscle wasting diseases. Expand
Analysis of iodinated quorum sensing peptides by LC–UV/ESI ion trap mass spectrometry
TLDR
Five different quorum sensing peptides (QSP) were iodinated using different iodination techniques, and depending on the used iodination method, iodination yields varied from low (2%) to high (57%). Expand
ITP-Pred: an interpretable method for predicting, therapeutic peptides with fused features low-dimension representation.
TLDR
An Interpretable Therapeutic Peptide Prediction (ITP-Pred) model based on efficient feature fusion was developed and indicated that ITP-Pred has a higher prediction performance on the benchmark dataset than other comparison methods. Expand
...
1
2
...

References

SHOWING 1-10 OF 25 REFERENCES
Detection of bacterial quorum sensing N-acyl homoserine lactones in clinical samples
TLDR
A method based on genetically engineered whole-cell sensing systems for the rapid, sensitive, cost-effective and quantitative detection of AHLs in biological samples from both healthy and diseased individuals with GI disorders is developed. Expand
Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides
TLDR
The Quorumpeps database is developed to give a structured overview of the QS oligopeptides, describing their microbial origin, functionality, functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). Expand
Peptide signal molecules and bacteriocins in Gram-negative bacteria: a genome-wide in silico screening for peptides containing a double-glycine leader sequence and their cognate transporters
TLDR
It was found that 33% of the screened genomes of Gram-negative bacteria contained one or more transporters carrying a Peptidase C39 domain, compared to 44% ofThe genomes of gram-positive bacteria. Expand
Quorum sensing in bacteria.
TLDR
The evolution of quorum sensing systems in bacteria could, therefore, have been one of the early steps in the development of multicellularity. Expand
Crosstalk between the microbiome and cancer cells by quorum sensing peptides
TLDR
It is discovered that certain quorum sensing peptides, produced by bacteria, interact with mammalian cells, in casu cancer cells: Phr0662 (Bacillus sp.), EntF-metabolite (Enterococcus faecium) and EDF-derived (Escherichia coli) peptides initiate HCT-8/E11 colon cancer cell invasion, with Phr 0662 also promoting angiogenesis. Expand
Quorum sensing in bacterial virulence.
TLDR
This article presents examples of how each of the major types of autoinducer can be involved in bacterial virulence and discusses some of the new strategies to combatacterial virulence based on the inhibition of bacterial quorum sensing systems. Expand
Quorum sensing: cell-to-cell communication in bacteria.
TLDR
This review focuses on the architectures of bacterial chemical communication networks; how chemical information is integrated, processed, and transduced to control gene expression; how intra- and interspecies cell-cell communication is accomplished; and the intriguing possibility of prokaryote-eukaryote cross-communication. Expand
The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal homeostasis via OCTN2, a host cell membrane transporter.
TLDR
The quorum-sensing pentapeptide, competence and sporulation factor, of the Gram-positive bacterium Bacillus subtilis activates key survival pathways, including p38 MAP kinase and protein kinase B (Akt), in intestinal epithelial cells, and serves as an example of a host-bacterial interaction that allows the host to monitor and respond to changes in the behavior or composition of colonic flora. Expand
Making sense of quorum sensing in lactobacilli: a special focus on Lactobacillus plantarum WCFS1.
TLDR
The predicted presence of multiple (peptide-based) QS-TCSs in some lactobacilli and in particular in L. plantarum might be a reflection of the ability of these species to persist in a diverse range of ecological niches. Expand
Quorum Sensing and Bacterial Social Interactions in Biofilms
TLDR
Understanding the molecular details of quorum sensing mechanisms and their controlled social activities may open a new avenue for controlling bacterial infections. Expand
...
1
2
3
...