Exploring the cellular accumulation of metal complexes.

  title={Exploring the cellular accumulation of metal complexes.},
  author={Cindy A Puckett and Russell J Ernst and Jacqueline K Barton},
  journal={Dalton transactions},
  volume={39 5},
Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters… CONTINUE READING

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