Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population‐based GENICA study and external genetic databases

@article{Bermejo2013ExploringTA,
  title={Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population‐based GENICA study and external genetic databases},
  author={J. Bermejo and M. Kabisch and Thomas D{\"u}nnebier and S. Schnaidt and F. Melchior and H. Fischer and Volker Harth and S. Rabstein and B. Pesch and T. Br{\"u}ning and Christina Justenhoven and H. Brauch and C. Baisch and Yon‐Dschun Ko and U. Hamann},
  journal={International Journal of Cancer},
  year={2013},
  volume={133}
}
  • J. Bermejo, M. Kabisch, +12 authors U. Hamann
  • Published 2013
  • Biology, Medicine
  • International Journal of Cancer
  • Small ubiquitin‐like modifier (SUMO) proteins are covalently attached to target proteins to modify their function. SUMO conjugation participates in processes tightly linked to tumorigenesis. Recently USPL1 (ubiquitin‐specific peptidase‐like (1) was identified as a SUMO isopeptidase. We report here on the first exploratory study investigating the relationship between genetic variability in USPL1 and breast cancer. Three potentially functional nonsynonymous coding SNPs (rs3742303, rs17609459… CONTINUE READING
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