Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design

@inproceedings{Pizarro2013ExploringTT,
  title={Exploring the Trypanosoma brucei Hsp83 Potential as a Target for Structure Guided Drug Design},
  author={Juan C Pizarro and Tanya Hills and Guillermo A. Senisterra and Amy K. Wernimont and Claire Mackenzie and Neil R. Norcross and Michael A. J. Ferguson and Paul G Wyatt and Ian H. Gilbert and Raymond Hui},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
Human African trypanosomiasis is a neglected parasitic disease that is fatal if untreated. The current drugs available to eliminate the causative agent Trypanosoma brucei have multiple liabilities, including toxicity, increasing problems due to treatment failure and limited efficacy. There are two approaches to discover novel antimicrobial drugs--whole-cell screening and target-based discovery. In the latter case, there is a need to identify and validate novel drug targets in Trypanosoma… CONTINUE READING