Exploring the Synthetic Applicability of a Cyanobacterium Nitrilase as Catalyst for Nitrile Hydrolysis

@inproceedings{Mukherjee2006ExploringTS,
  title={Exploring the Synthetic Applicability of a Cyanobacterium Nitrilase as Catalyst for Nitrile Hydrolysis},
  author={Chandrani Mukherjee and Dunming Zhu and Edward R. Biehl and Ling Jun Hua},
  year={2006}
}
The substrate specificity and synthetic applicability of the nitrilase from cyanobacterium Synechocystis sp. strain PCC 6803 have been examined. This nitrilase catalyzed the hydrolysis of both aromatic and aliphatic nitriles to the corresponding acids in high yields. Furthermore, the stereoselective hydrolysis of phenyl-substituted β-hydroxy nitriles to (S)-enriched β-hydroxy carboxylic acids and selective hydrolysis of α,ω-dinitriles with five or less methylene groups to ω-cyano carboxylic… CONTINUE READING