Exploring the Potential of Flubendazole in Filariasis Control: Evaluation of the Systemic Exposure for Different Pharmaceutical Preparations

@inproceedings{Ceballos2014ExploringTP,
  title={Exploring the Potential of Flubendazole in Filariasis Control: Evaluation of the Systemic Exposure for Different Pharmaceutical Preparations},
  author={Laura Sanz Ceballos and Charles Mackenzie and Timothy R. Geary and Luis Omar Sarmiento Alvarez and Carlos E. Lanusse},
  booktitle={PLoS neglected tropical diseases},
  year={2014}
}
The goal of elimination of the human filariases would benefit greatly from the use of a macrofilaricidal agent. In vivo trials in humans and many experimental animal models suggest that flubendazole (FLBZ) is a highly efficacious macrofilaricide. However, since serious injection site reactions were reported in humans after parenteral FLBZ administration, the search for alternative pharmaceutical strategies to improve the systemic availability of FLBZ and its metabolites has acquired urgency in… CONTINUE READING
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