Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation

  title={Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation},
  author={Riya Shrestha and P. Cho and Sanjita Paudel and Aarajana Shrestha and M. Kang and T. Jeong and Eung-Seok Lee and Sangkyu Lee},
Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug that is reduced to its active metabolite, trans-alcohol form (Trans-OH) by carbonyl reductase enzyme in the liver. Previous studies demonstrated the hydroxylation and glucuronidation of loxoprofen. However, the specific enzymes catalyzing its metabolism have yet to be identified. In the present study, we investigated metabolic enzymes, such as cytochrome P450 (CYP) and UDP-glucuronosyltransferase… Expand
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A novel mass spectrometry method for the absolute quantification of several cytochrome P450 and uridine 5′-diphospho-glucuronosyltransferase enzymes in the human liver
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Determination of Trans-loxoprofen-alcohol Tromethamine in Pregnant SD rats by a Validated LC-MS/MS method:Application to a Toxicokinetics and Tissue Distribution study
Background: As an anti-inflammatory prodrug, loxoprofen is metabolized into transloprofenol to treat diseases related to pain and inflammation. Although loxoprofen has fewer adverse effects thanExpand
Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital
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Plant Archives
e-ISSN:2581-6063 (online), ISSN:0972-5210 Plant Archives Volume 21, No 1, 2021 pp. 1838-1841 DOI Url: https://doi.org/10.51470/PLANTARCHIVES.2021.v21.no1.252


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Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism.
ABSTRACT: The objective of this study was to characterize the extent of the formation of the active ( trans -alcohol form) and inactive ( cis -alcohol) metabolites of loxoprofen and to compare theExpand