Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation

@article{Shrestha2018ExploringTM,
  title={Exploring the Metabolism of Loxoprofen in Liver Microsomes: The Role of Cytochrome P450 and UDP-Glucuronosyltransferase in Its Biotransformation},
  author={Riya Shrestha and P. Cho and Sanjita Paudel and Aarajana Shrestha and M. Kang and T. Jeong and Eung-Seok Lee and Sangkyu Lee},
  journal={Pharmaceutics},
  year={2018},
  volume={10}
}
Loxoprofen, a propionic acid derivative, non-steroidal anti-inflammatory drug (NSAID) is a prodrug that is reduced to its active metabolite, trans-alcohol form (Trans-OH) by carbonyl reductase enzyme in the liver. Previous studies demonstrated the hydroxylation and glucuronidation of loxoprofen. However, the specific enzymes catalyzing its metabolism have yet to be identified. In the present study, we investigated metabolic enzymes, such as cytochrome P450 (CYP) and UDP-glucuronosyltransferase… Expand
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Plant Archives
e-ISSN:2581-6063 (online), ISSN:0972-5210 Plant Archives Volume 21, No 1, 2021 pp. 1838-1841 DOI Url: https://doi.org/10.51470/PLANTARCHIVES.2021.v21.no1.252

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