Exploring the MHC-peptide matrix of central tolerance in the human thymus.

@article{Adamopoulou2013ExploringTM,
  title={Exploring the MHC-peptide matrix of central tolerance in the human thymus.},
  author={Eleni Adamopoulou and Stefan Tenzer and Nina Hillen and Paula Klug and Ioanna Alexandros Rota and Silvia M Tietz and Madlen Gebhardt and Stefan Stevanovi{\'c} and Hansjoerg Schild and Eva Tolosa and Arthur Melms and Christina Stoeckle},
  journal={Nature communications},
  year={2013},
  volume={4},
  pages={2039}
}
Ever since it was discovered that central tolerance to self is imposed on developing T cells in the thymus through their interaction with self-peptide major histocompatibility complexes on thymic antigen-presenting cells, immunologists have speculated about the nature of these peptides, particularly in humans. Here, to shed light on the so-far unknown human thymic peptide repertoire, we analyse peptides eluted from isolated thymic dendritic cells, dendritic cell-depleted antigen-presenting… CONTINUE READING