Exploring the LPS/TLR4 signal pathway with small molecules.

  title={Exploring the LPS/TLR4 signal pathway with small molecules.},
  author={Francesco Peri and Matteo Piazza and Valentina Calabrese and Gaetana Damore and Roberto Cighetti},
  journal={Biochemical Society transactions},
  volume={38 5},
The identification of the bacterial endotoxin receptors for innate immunity, most notably TLR4 (Toll-like receptor 4), has sparked great interest in therapeutic manipulation of the innate immune system. In the present mini-review, several natural and synthetic molecules that modulate the TLR4-mediated LPS (lipopolysaccharide) signalling in animals and humans are considered, and their mechanisms of action are discussed. The process of LPS sensing and signal amplification in humans is based on… CONTINUE READING
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