Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models

Abstract

A low level of tissue oxygen (hypoxia) is a physiological feature of a wide range of diseases, from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydroxylase enzymes, which regulate the protein stability of hypoxia-inducible factor α (HIF-α) transcription factors. When stabilised, HIF-α binds with its cofactors to HIF-responsive… (More)
DOI: 10.1242/dmm.021865

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Cite this paper

@inproceedings{Elks2015ExploringTH, title={Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models}, author={Philip M. Elks and Stephen A. Renshaw and Annemarie H. Meijer and Sarah R. Walmsley and Fredericus J. M. van Eeden}, booktitle={Disease models & mechanisms}, year={2015} }