Exploring the Alzheimer amyloid-β peptide conformational ensemble: A review of molecular dynamics approaches.

Abstract

Alzheimer's disease is one of the most common dementia among elderly worldwide. There is no therapeutic drugs until now to treat effectively this disease. One main reason is due to the poorly understood mechanism of Aβ peptide aggregation, which plays a crucial role in the development of Alzheimer's disease. It remains challenging to experimentally or… (More)
DOI: 10.1016/j.peptides.2015.04.009

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