Exploring neural dysfunction in 'clinical high risk' for psychosis: a quantitative review of fMRI studies.

@article{Dutt2015ExploringND,
  title={Exploring neural dysfunction in 'clinical high risk' for psychosis: a quantitative review of fMRI studies.},
  author={Anirban Dutt and Huai-Hsuan Tseng and Leon Michel Fonville and Mark Drakesmith and Liang Su and John Spencer Evans and Stanley Zammit and Derek K Jones and Glyn Lewis and Anthony S David},
  journal={Journal of psychiatric research},
  year={2015},
  volume={61},
  pages={
          122-34
        }
}
Individuals at clinical high risk (CHR) of developing psychosis present with widespread functional abnormalities in the brain. Cognitive deficits, including working memory (WM) problems, as commonly elicited by n-back tasks, are observed in CHR individuals. However, functional MRI (fMRI) studies, comprising a heterogeneous cluster of general and social cognition paradigms, have not necessarily demonstrated consistent and conclusive results in this population. Hence, a comprehensive review of… CONTINUE READING
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