Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.

  title={Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.},
  author={Sanmitra Barman and Lei You and Ran Chen and Vlad Codrea and Grace Kago and Ramakrishna Edupuganti and Jon D. Robertus and Robert Krug and Eric V Anslyn},
  journal={European journal of medicinal chemistry},
A library of hydrazide derivatives was synthesized to target non-structural protein 1 of influenza A virus (NS1) as a means to develop anti-influenza drug leads. The lead compound 3-hydroxy-N-[(Z)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)ethylideneamino]naphthalene-2-carboxamide, which we denoted as "HENC", was identified by its ability to increase the melting temperature of the effector domain (ED) of the NS1 protein, as assayed using differential scanning fluorimetry. A library of HENC analogs… CONTINUE READING
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