Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy.

@article{Ct2006ExploringMN,
  title={Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy.},
  author={H{\'e}l{\`e}ne Cf C{\^o}t{\'e} and Alexander B. Magil and Marianne Harris and Brian J. Scarth and Izabelle Gadawski and Nancy Wang and Eugenia Yu and Benita Yip and Nadia Zalunardo and Ron Werb and Robert Hogg and P. Richard Harrigan and Julio S. G. Montaner},
  journal={Antiviral therapy},
  year={2006},
  volume={11 1},
  pages={79-86}
}
BACKGROUND Tenofovir (TDF) exposure has been associated with renal dysfunction. Mitochondrial nephrotoxicity was investigated as an underlying mechanism. Given the interaction between TDF and didanosine (ddl), their concurrent use was also investigated. DESIGN Relative kidney biopsy mitochondrial DNA (mtDNA) to nuclear DNA ratios were measured retrospectively. HIV+ individuals on TDF within 6 months preceeding the biopsy (HIV+/TDF+, n=21) were compared to HIV+ individuals who never received… CONTINUE READING

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Relative kidney biopsy mitochondrial DNA ( mtDNA ) to nuclear DNA ratios were measured retrospectively . HIV+
Relative kidney biopsy mitochondrial DNA ( mtDNA ) to nuclear DNA ratios were measured retrospectively . HIV+
Relative kidney biopsy mitochondrial DNA ( mtDNA ) to nuclear DNA ratios were measured retrospectively . HIV+
Relative kidney biopsy mitochondrial DNA ( mtDNA ) to nuclear DNA ratios were measured retrospectively . HIV+
Relative kidney biopsy mitochondrial DNA ( mtDNA ) to nuclear DNA ratios were measured retrospectively . HIV+
In regression analyses , only HIV infection ( P=0.03 ) , and TDF / ddl use ( P=0.003 ) were associated with lower mtDNA .
In regression analyses , only HIV infection ( P=0.03 ) , and TDF / ddl use ( P=0.003 ) were associated with lower mtDNA .
Relative kidney biopsy mitochondrial DNA ( mtDNA ) to nuclear DNA ratios were measured retrospectively . HIV+
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