Exploring long-range proton conduction, the conduction mechanism and inner hydration state of protein biopolymers†

  title={Exploring long-range proton conduction, the conduction mechanism and inner hydration state of protein biopolymers†},
  author={Somen Mondal and Y. Agam and R. Nandi and N. Amdursky},
  journal={Chemical Science},
  pages={3547 - 3556}
Proteins are the main proton mediators in various biological proton circuits. Using proteins for the formation of long-range proton conductors is offering a bioinspired approach for proton conductive polymers. One of the main challenges in the field of proton conductors is to explore the local environment within the polymers, along with deciphering the conduction mechanism. Here, we show that the protonic conductivity across a protein-based biopolymer can be hindered using straightforward… Expand
5 Citations

Figures and Tables from this paper

Enhanced Proton Conductivity across Protein Biopolymers Mediated by Doped Carbon Nanoparticles.
It is shown that C-Dots can also mediate protons, where protein biopolymers are used as the protonic transport matrix, resulting in one of the highest measured proton conductivity across proteinBiopolymers. Expand
Long-range light-modulated charge transport across the molecular heterostructure doped protein biopolymers†
It is shown that the rapid intramolecular charge separation happens following light excitation, which can be ascribed to an ultrafast electron and hole transfer (HT) from the C-Dot donor to the hemin acceptor, thus making an electron donor–acceptor system. Expand
Proton conduction in inkjet-printed reflectin films
Biomolecular proton conducting materials have been touted as promising for seamlessly and directly interfacing natural biological systems with traditional artificial electronics. As such, protonExpand
The role of the protein–water interface in dictating proton conduction across protein-based biopolymers
The role of different water states and their interface with a protein microstructure in mediating protons has been investigated using several approaches, concluding on the importance of theExpand


Significant Enhancement of Proton Transport in Bioinspired Peptide Fibrils by Single Acidic or Basic Amino Acid Mutation
Bioinspired materials are extremely suitable for the development of biocompatible and environmentally friendly functional materials. Peptide-based assemblies are remarkably attractive for such tasks,Expand
Kinetics of proton transport in water
The excess proton mobility in water has attracted scientific attention for more than a century. Detailed theoretical concepts and models are also presently in strong focus in efforts towardExpand
Bulk protonic conductivity in a cephalopod structural protein.
This work reports proton conductivity for thin films composed of reflectin, a cephalopod structural protein, and finds it possible to use reflectin in protein-based protonic transistors, which may hold implications for the next generation of biocompatible proton-conducting materials and Protonic devices. Expand
Biological water at the protein surface: Dynamical solvation probed directly with femtosecond resolution
  • S. Pal, J. Peón, A. Zewail
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Results show that hydration at the surface is a dynamical process with two general types of trajectories, those that result from weak interactions with the selected surface site, giving rise to bulk-type solvation, and those that have a stronger interaction, enough to define a rigid water structure, with a solvation time of 38 ps, much slower than that of the bulk. Expand
Proton transfer pathways in bacteriorhodopsin at 2.3 angstrom resolution.
X-ray diffraction of bacteriorhodopsin crystals grown in cubic lipid phase revealed unexpected two-fold symmetries that indicate merohedral twinning along the crystallographic c axis. Expand
Is a “Proton Wire” Concerted or Stepwise? A Model Study of Proton Transfer in Carbonic Anhydrase
The energetics of proton transfer reactions in carbonic anhydrase (CA) have been studied with an active site model. Specifically, proton transfer from a zinc-bound water molecule to a histidineExpand
Microscopic Insight into the Protein Denaturation Action of Urea and Its Methyl Derivatives.
These urea derivatives, especially tetramethylurea, can effectively disrupt hydrophobic interactions in proteins and promote intramolecular hydrogen-bond formation and hence induce α-helix folding in peptides, as observed. Expand
Ultrafast solvation dynamics of human serum albumin: correlations with conformational transitions and site-selected recognition.
These systematic studies of solvation dynamics and local rigidity in these conformations using a single intrinsic tryptophan (W214) residue as a local molecular probe report a robust bimodal distribution of time scales for all conformational isomers. Expand
Voltage-gated proton channels and other proton transfer pathways.
Voltage-gated proton channels represent a specific subset of proton channel that have voltage- and time-dependent gating like other ion channels, but differ from most ion channels in their extraordinarily high selectivity, tiny conductance, strong temperature and deuterium isotope effects on conductance and gating kinetics, and insensitivity to block by steric occlusion. Expand
Macroscale Biomolecular Electronics and Ionics.
The underlying principles of conduction on the macroscale in biomolecular materials are discussed, highlighting recent examples, and particularly the establishment of accurate structure-property relationships to guide rationale material and device design. Expand