Exploring hyponatremia in older hospital in-patients: management, association with falls, and other adverse outcomes

  title={Exploring hyponatremia in older hospital in-patients: management, association with falls, and other adverse outcomes},
  author={Jana M. Valle and Alexander Beveridge and Danielle N{\'i} Chr{\'o}in{\'i}n},
  journal={Aging and Health Research},



Active management of hyponatraemia and mortality in older hospitalised patients compared with younger patients: results of a prospective cohort study.

Despite greater rates of HN-targeted treatment, the risk of in-hospital death is increased in older hyponatraemic patients compared with older eunatraemic controls, and the impact ofHyponatraemia on mortality is even greater in younger patients.

Active management of severe hyponatraemia is associated with improved mortality.

Dedicated specialist management of severe hyponatraemia is associated with a reduction in mortality, to rates comparable with moderate hyp onatraemia.

Sub‐acute hyponatraemia more than chronic hyponatraemia is associated with serious falls and hip fractures

The effect of hyponatraemia duration is not well understood, but the risk for falls/hip fractures among older people is associated with high morbidity and mortality.

Morbidity and Mortality of Hyponatremia.

  • A. Peri
  • Medicine
    Frontiers of hormone research
  • 2019
There is convincing evidence that the mortality risk is reduced when hyponatremia improves, and this condition has been clearly associated with a significantly increased risk of death, even when serum [Na+] is slightly reduced.

Interventions for chronic non-hypovolaemic hypotonic hyponatraemia.

If benefits and harms vary in absolute or relative terms dependent on the specific compound within a drug class, on the dosage used, or the underlying disorder causing the hyponatraemia is determined, it is found that vasopressin receptor antagonists may reduce hospital stay and may make little or no difference to cognitive function.

Hyponatraemia in Hospitalised Adults: a Guide for the Junior Doctor

Recommendations are largely based on the 2014 joint European clinical practice guidance for management of hyponatraemia; the 2010 GAIN (N Ireland) guidance and 2013 American guidance are also referenced.

Impact of hyponatremia on nerve conduction and muscle strength

Hyponatremia is associated with unstable gait and propensity to falls. The potential contribution of peripheral nervous system dysfunction induced by hyponatremia has not yet been addressed by

Disturbed fluid and electrolyte homoeostasis following dehydration in elderly people.

It is of interest that the arginine vasopressin (AVP) response to dehydration is maintained in elderly subjects, indicating that their reduced renal water retentive capacity is due to relative renal resistance to vasopice, and the mechanism underlying the reduced thirst is unclear.