Exploring glyoxalase 1 expression in prostate cancer tissues: targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties.

@article{Baunacke2014ExploringG1,
  title={Exploring glyoxalase 1 expression in prostate cancer tissues: targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties.},
  author={Martin Baunacke and Lars-Christian Horn and Susanne Trettner and Kathrin Engel and Nasr Y A Hemdan and Volker Wiechmann and Jens-Uwe Stolzenburg and Marina Bigl and Gerd Birkenmeier},
  journal={The Prostate},
  year={2014},
  volume={74 1},
  pages={48-60}
}
BACKGROUND The glyoxalase (GLO)1 is part of a ubiquitous detoxification system in the glycolytic pathway of normal and tumor cells. It protects against cellular damage caused by cytotoxic metabolites. METHODS Aiming at exploring the role of GLO1 in prostate cancer, we evaluated and targeted the expression of GLO1 in prostate cancer tissues and cell lines and analyzed its correlation with grading systems and tumor growth indices. RESULTS Immunohistochemical studies on 37 prostate cancer… CONTINUE READING