Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips.

@article{Shen2013ExploringGD,
  title={Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips.},
  author={Jing Shuang Shen and Shuang Wang and Yu-jing Zhang and Hui-Chen Wu and Muhammad G Kibriya and Farzana Jasmine and Habibul Ahsan and David Ping-Hsin Wu and Abby B. Siegel and Helen Remotti and Regina M. Santella},
  journal={Epigenetics},
  year={2013},
  volume={8 1},
  pages={
          34-43
        }
}
Hepatocellular carcinoma (HCC) incidence has increased in the US and also has one of the fastest growing death rates of any cancer. The purpose of the current study was to discover novel genome-wide aberrant DNA methylation patterns in HCC tumors that are predominantly HCV-related. Infinium HumanMethylation 450K BeadChip arrays were used to examine genome-wide DNA methylation profiles in 66 pairs of HCC tumor and adjacent non-tumor tissues. After Bonferroni adjustment, a total of 130,512 CpG… CONTINUE READING
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