Exploring functional in vivo consequences of the selective genetic ablation of mTOR signaling in T helper lymphocytes.


The mammalian Target of Rapamycin (mTOR) defines a crucial link between nutrient sensing and immune function. In CD4+ T cells, mTOR has been shown to play a critical role in regulating effector and regulatory T cell differentiation as well as the decision between full activation versus the induction of anergy. In this chapter, we describe how our group has… (More)
DOI: 10.1007/978-1-61779-430-8_20


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