Exploring folding free energy landscapes using computational protein design.

@article{Kuhlman2004ExploringFF,
  title={Exploring folding free energy landscapes using computational protein design.},
  author={Brian Kuhlman and David Baker},
  journal={Current opinion in structural biology},
  year={2004},
  volume={14 1},
  pages={89-95}
}
Recent advances in computational protein design have allowed exciting new insights into the sequence dependence of protein folding free energy landscapes. Whereas most previous studies have examined the sequence dependence of protein stability and folding kinetics by characterizing naturally occurring proteins and variants of these proteins that contain a small number of mutations, it is now possible to generate and characterize computationally designed proteins that differ significantly from… CONTINUE READING

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