Exploring environmental causes of altered ras effects: Fragmentation plus integration?

@article{Porta2003ExploringEC,
  title={Exploring environmental causes of altered ras effects: Fragmentation plus integration?},
  author={M. Porta and D. Ayude and J. Alguacil and Manuel Jariod},
  journal={Molecular Carcinogenesis},
  year={2003},
  volume={36}
}
Mutations in ras genes are the most common abnormality of oncogenes in human cancer and a major example of activation by point mutation. Experimental and epidemiological studies support the notion that Ki‐ras activation and expression may be chemically related. We discuss the potential role of several environmental compounds in the induction or promotion of ras mutations in humans, with a focus on exocrine pancreatic cancer, the human tumor with the highest prevalence at diagnosis of Ki‐ras… Expand
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