Exploring environmental causes of altered ras effects: Fragmentation plus integration?

@article{Porta2003ExploringEC,
  title={Exploring environmental causes of altered ras effects: Fragmentation plus integration?},
  author={M. Porta and D. Ayude and J. Alguacil and Manuel Jariod},
  journal={Molecular Carcinogenesis},
  year={2003},
  volume={36}
}
Mutations in ras genes are the most common abnormality of oncogenes in human cancer and a major example of activation by point mutation. Experimental and epidemiological studies support the notion that Ki‐ras activation and expression may be chemically related. We discuss the potential role of several environmental compounds in the induction or promotion of ras mutations in humans, with a focus on exocrine pancreatic cancer, the human tumor with the highest prevalence at diagnosis of Ki‐ras… Expand
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22 Citations
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22 Citations

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Review: Coffee drinking: The rationale for treating it as a potential effect modifier of carcinogenic exposures
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Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K‐ras activation in human exocrine pancreatic cancer
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In pancreatic ductal adenocarcinoma blood concentrations of some organochlorine compounds and coffee intake are independently associated with KRAS mutations.
  • 21
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The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer.
  • 17
Concentrations of trace elements and KRAS mutations in pancreatic ductal adenocarcinoma
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Diet, lifestyle and risk of K‐ras mutation‐positive and ‐negative colorectal adenomas
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K-ras Mutation and p16 and Preproenkephalin Promoter Hypermethylation in Plasma DNA of Pancreatic Cancer Patients: In Relation to Cigarette Smoking
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Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.
  • 12
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Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: etiopathogenic similarities, differences and paradoxes.
  • 67
Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients
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References

SHOWING 1-10 OF 153 REFERENCES
The ras gene family and human carcinogenesis.
  • J. L. Bos
  • Biology, Medicine
  • Mutation research
  • 1988
  • 749
Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride.
  • 59
Mutant c-Ki-ras p21 protein in chemical carcinogenesis in humans exposed to vinyl chloride
  • 28
Vinyl chloride-specific mutations in humans and animals.
  • 26
Activation of Ki‐ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure
  • 74
Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure.
  • 18
Dietary fish oil inhibits the expression of farnesyl protein transferase and colon tumor development in rodents.
  • 33
  • PDF
Increasing complexity of Ras signaling
  • 1,072
  • PDF
The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice.
  • 14
ras gene mutations in vinyl chloride‐induced liver tumours are carcinogen‐specific but vary with cell type and species
  • 40
...
1
2
3
4
5
...