Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics.

@article{Tekade2009ExploringDT,
  title={Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics.},
  author={Rakesh Kumar Tekade and Tathagata Dutta and Virendra Gajbhiye and Narendra Kumar Jain},
  journal={Journal of microencapsulation},
  year={2009},
  volume={26 4},
  pages={287-96}
}
A major problem associated with conventional leukaemia chemotherapy is the development of resistance that can be surmounted well by combination chemotherapy. The objective of the present investigation is to report a novel technology to load two anti-leukaemic drugs of choice simultaneously inside the PAMAM dendrimer. Under optimized conditions of pH and dialysis time, one molecule of PAMAM dendrimer was found to be capable of entrapping 27.02 ± 0.51 and 8.00 ± 0.46 molecules of Methotrexate and… CONTINUE READING

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