Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook.

Abstract

RNA interference (RNAi) is a post-transcriptional gene silencing mechanism induced by small interfering RNAs (siRNAs) and micro-RNAs (miRNAs), and has proved to be one of the most important scientific discoveries made in the last century. The robustness of RNAi has opened up new avenues in the development of siRNAs as therapeutic agents against various… (More)
DOI: 10.1002/cmdc.200900444

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