Exploring associations of 6-thioguanine nucleotide levels and other predictive factors with therapeutic response to azathioprine in pediatric patients with IBD using multilevel analysis.

@article{Nguyen2013ExploringAO,
  title={Exploring associations of 6-thioguanine nucleotide levels and other predictive factors with therapeutic response to azathioprine in pediatric patients with IBD using multilevel analysis.},
  author={Thi-Van-Anh Nguyen and Dinh Hoa Vu and Thi-Mai-Hoang Nguyen and Alain Lachaux and Roselyne Boulieu},
  journal={Inflammatory bowel diseases},
  year={2013},
  volume={19 11},
  pages={
          2404-10
        }
}
BACKGROUND Metabolite monitoring and response predictors to azathioprine (AZA) in pediatric inflammatory bowel disease (IBD) are debatable. In an attempt to optimize thiopurine therapy and understand the mechanism of action of thiopurines, we correlated metabolites and other factors with AZA efficacy in children with IBD. METHODS Data from 86 children with IBD with 440 metabolite measurements were retrospectively analyzed using multilevel logistic regression analyses. A therapeutic response… CONTINUE READING
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